Experimental animal studies have shown that MGB deregulation in early life is correlated with GD, reduced brain-derived neurotrophic factor (BDNF), increased HPA axis activation, impaired glucocorticoid receptor-mediated negative feedback, increased stress reactivity, aberrated brain development, and abnormal behavior such as impaired social interaction, anxious-like, cognitive deficit, and other metabolic, immune or psychological disorders in adulthood [94,95,96]. This evidence concerns the gene BDNF and Cognitive impairment.