However, the ablation of STING and type I interferon signaling by genetic deletion of downstream innate immune mediators STING and IFNAR failed to rescue infertility and testis involution, as shown by the lack of mature sperm in the double-mutant CLPP-null/STING-KnockOut (KO) and CLPP-null/IFNAR-KO testis (Figure S7d,e). This evidence concerns the gene STING1 and Infertility.