However, the ablation of STING and type I interferon signaling by genetic deletion of downstream innate immune mediators STING and IFNAR failed to rescue infertility and testis involution, as shown by the lack of mature sperm in the double-mutant CLPP-null/STING-KnockOut (KO) and CLPP-null/IFNAR-KO testis (Figure S7d,e). The gene discussed is CLPP; the disease is Infertility.