POSTN and congenital rubella syndrome: Periostin-induced tissue remodeling by activating the Src/AKT/mTOR signaling pathway and inducing myofibroblasts differentiation and expression of ECM or by enhancing the mRNA expression of MMP-3, MMP-7, MMP-8, and MMP-9 in fibroblasts and MMP-9 in epithelial cells in CRS.