HBB and cyst: We found that the CD-PC-Conserved cells in day 21 Pkd1 HOMO kidneys not only expressed marker genes characteristic of this population, but also expressed high levels of metabolism-related genes, including Aldob, Gpx1, Gpx3, Glyat, Gsta2, and Hbb (Figure 2i), which are related to oxygen metabolism and mitochondrial function, suggesting a high metabolic state for this cell subtype at this late stage of cyst progression.