PTH1R and hyperparathyroidism: A more recent study indicated that Pitt12 (MolPort ID: 039-313-655), binding at a druggable site located within the PTH1R, caused a decrease in the kinetics and magnitude of G proteins (Gs and Gq) association with the PTH1R, serving as an allosteric antagonist candidate for the treatment of hyperparathyroidism [23].