A more sophisticated approach would be the combination of the Eμ-Myc transgene with Cre recombinases that delete in germinal center B-cells, such as AID-cre, CD21-cre, or Cγ1-cre to study mature B-cell lymphomas with the respective genetic deletion [63,64,65]. This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.