MYC and neoplasm: At last, the combination of an established MYC-driven cancer mouse model, such as Eμ-Myc (Table 1), with modern-day technologies, such as spatial single-cell sequencing, might be helpful to resolve intercellular differences in MYC expression tracking the acquisition of secondary mutations in vivo and to clarify the role of MYC in the tumor microenvironment All these efforts will eventually be rewarded with a deeper understanding of MYC-dependent lymphomagenesis, pointing toward future therapies.