Interestingly, B-cell-specific KO of Trp53 with Mb1-cre resulted in the development of B-cell lymphomas harboring oncogenic translocations, including Igh/Myc—very similar to Eμ-Myc transgenic mice—and a median survival of 28 days [76]. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.