AMOP-containing proteins have conserved cysteine (C) residues, while AMOP in both ISM1 and ISM2 also possesses a KGD motif that binds to the integrin αIIbβ3 present in the multiple antagonists of platelet aggregation and is engaged in the integrin-mediated cellular adhesion and tumour metastasis [24] (see Figure 5). Here, ISM1 is linked to neoplasm.