ISM1 and hepatocellular carcinoma: Furthermore, in hepatocellular carcinoma (HCC), cell proliferation and migration are reported to be promoted by ISM1 and regulated by the interaction with circular RNA (circRNA) and micro RNA (miRNA), namely hsa_circ_0091570/miR-1307 hsa_circ_0091570, which competitively binds to miR-1307 by serving as the ceRNA (competing endogenous RNA) that then regulates ISM1 expression [65].