However, it is worth noting that studies have shown that PTPRJ expression is higher in highly invasive breast cancer cells (MDA-MB-231, Hs578T, and BT-549) than in non-transformed or less invasive breast cancer cell lines (MCF-7, T47D, SK-BR3, and MCF10A) [51], contrary to the significantly reduced expression of PTPRJ in many malignancies we mentioned earlier. This evidence concerns the gene PTPRJ and breast cancer.