ENPP3 and chronic myelogenous leukemia, BCR-ABL1 positive: Interestingly, compared to normal basophils, IgE receptor-dependent upregulation of CD203c on CML basophils was less pronounced which may be explained by the fact that CML basophils are in part more immature cells expressing lower levels of IgE receptors and therefore are less responsive to IgE-dependent activation.