IL6 and acute liver failure: In patients with acute liver failure, persistent infection also leads to a decrease in the liver’s ability to clear LPS, a 2- to 7-fold increase in the release of inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin 6 (IL6), and an increase in circulating aminotransferases, thus aggravating liver function injury [16].