Assessing NGAL locally in the inflamed joint was suggested to be more sensitive than serum measurements, and with its fast rise-and-fall pattern (concentrations in SF peaked 8 h after joint inflammation had been elicited by intraarticular injection of LPS), it was suggested that this analyte might be particularly well suited for the early diagnosis and monitoring of joint inflammation [20]. The gene discussed is LCN2; the disease is Arthritis.