However, QLJP inhibited the TGF-β1/Smad2 signaling pathway, down-regulated the expression levels of α-SMA, COL1A1, MMP2, and improved pulmonary fibrosis and pulmonary arteriole remodeling induced by low-temperature exposure to play a role in the prevention and treatment of PAH. Here, ACTA1 is linked to pulmonary fibrosis.