CALR and myeloproliferative disorder: Aside from the JAK2, CALR and MPL genes that hold the prognostic significance in MPN, other non-driver mutations, such as ASXL1, TET2, SRSF2, IDH2, SH2B3, SF3B1, U2AF1, TP53, and EZH2, were found to not carry any prognostic significance [138].