PSMA PET in this setting will be helpful in detecting the tumour foci and subsequently guiding a targeted biopsy, particularly in patients with negative (Prostate Imaging-Reporting and Data System, PIRADS 1 or 2) or inconclusive (PIRADS 3) mpMRI findings and clinical or biochemical features highly suggestive of PCa, hence increases the diagnostic accuracy (Figure 1). This evidence concerns the gene FOLH1 and posterior cortical atrophy.