ACE2 and viral infectious disease: The proposed miR-221-3p mechanisms may be severe endothelial injury and coagulopathy (features observed in lung samples of fatal COVID-19 cases) [56] to the targeting core receptor protein ADAM17 (a disintegrin and metalloproteinase 17) involved in ACE2-dependent shedding (associated with lung pathogenesis) [57], and to the suppression of the innate immune response and promotion of the viral infection via the TBK1 (TANK binding kinase 1) gene [58,59].