TLR1 and respiratory tract infectious disorder: The association between genomic variants and a risk of respiratory infections or the severity of these conditions with a special focus on SARS-CoV-2 has shown that rs5743551 is associated with higher TLR1-induced NF-κB activation; higher cell surface TLR1 expression; and increased susceptibility to organ dysfunction, death, and Gram-positive infection in sepsis [12].