SHOX and hyperinsulinemic hypoglycemia, familial, 4: The risk of a child inheriting the SHOX gene deficiency is 50% when one of the parents is affected; if both parents are SHOX gene-deficient, there is a 50% risk of moderate-to-mild hypostature by SHOX deficiency, a 25% chance of severe Langer dwarfism, and a 25% chance of having none of the conditions [26].