In the same study, the analysis of RNA sequencing data from a cohort of SCCHN from The Cancer Genome Atlas tumor bank revealed that both HPV-negative and -positive tumors with strong immune infiltrate of CD8+ tumor-infiltrating lymphocytes (TILs) and natural killer cells had a survival benefit compared to tumors with less robust immune infiltrate [72]. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.