In Caballeria’s study, aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) ≥40 IU/L were associated with a two-fold increased risk of VCTE ≥8 kPa independently of T2DM, obesity and dyslipidemia [14]. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.