However, patient #1 showed immunopositivity for pan-TRK (Roche/Ventana) and a novel in frame KCTD8::NTRK2 fusion, involving exon 1 of KCTD8 and exon 16 of NTRK2 by RNA sequencing, in part coherent with the methylation findings of the v12.3 brain tumor classifier (with the bias of the low tumor content). The gene discussed is KCTD8; the disease is neoplasm.