KCTD8 and brain neoplasm: However, patient #1 showed immunopositivity for pan-TRK (Roche/Ventana) and a novel in frame KCTD8::NTRK2 fusion, involving exon 1 of KCTD8 and exon 16 of NTRK2 by RNA sequencing, in part coherent with the methylation findings of the v12.3 brain tumor classifier (with the bias of the low tumor content).