Recently, it has been reported that TDP-43 levels in CSF were higher in patients with FTD and ALS than in controls, using Western blot along with chemiluminescence assays [146], while similar results were obtained by measuring TDP-43 in the CSF of patients with early-stage ALS using the ELISA technique [147,148]. Here, TARDBP is linked to amyotrophic lateral sclerosis.