MAPT and Alzheimer disease: Pascoal et al. (2021), by using novel positron emission tomography (PET) brain imaging for capturing microglial, amyloid, and tau pathology, found that microglia activation correlates with tau pathology progression according to the stereotypical pattern of propagation of tau tangles from the transentorhinal/entorhinal to sensorimotor cortices in AD (known as Braak stages) [52].