RAF1 and RASopathy: In the remaining 25 fetuses, the multigene RASopathy panel was performed: in 3 cases (1 male, 2 females), a pathogenic variant was identified: c.179_181delTGG in PTPN11 (NM_002834.5, MIM*176876), c.770C>T, p.(Ser257Leu) in RAF1 (NM_002880.4, MIM*164760) and c.807_808delinsTT, p.(Gln269_His270delinsHisTyr) in SHOC2 (NM_007373.4, MIM*602775) [104].