PROS1 and cancer: Cancer cells can acquire multidrug resistance by directly exporting or sequestering cytotoxic drugs via EVs, and also confer a resistance phenotype to drug-sensitive cancer cells by transmitting cargo such as mRNAs, ncRNAs, lipids, and drug-resistance-related proteins (e.g., anti-apoptotic proteins, drug efflux transporters, etc.)that interfere with cell cycle control and induce anti-apoptotic signaling in recipient sensitive cells [30].