CD63 and pancreatic ductal adenocarcinoma: Odaka et al. [41] demonstrated elevated levels of platelet marker (CD41 and CD61)-positive and tetraspanin (CD63)-positive EVs in sera isolated from pancreatic ductal adenocarcinoma (PDAC) patients, particularly sera CD63+-EVs that showed promising diagnostic performance in separating PDAC patients from healthy subjects, with an area under the curve (AUC) value of 0.846.