VEGFA and neoplasm: Tumor-derived EVs have also been shown to induce angiogenic switch from physiologic to pathologic angiogenesis through the significant release of pro-angiogenic factors, such as matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), and non-coding RNAs (ncRNAs, e.g., microRNAs and long non-coding RNAs), to activate pro-angiogenic activities in the adjacent vasculature, leading to pathologic neovascularization that supports tumor growth [27].