Another study describes that whilst WMHs with demyelinating characteristics are more frequent with younger age and altered glomerular filtration rate, the total number of WMHs, however, is associated with higher age (contrary to the findings of Govoni et al.)as well as lower prevalence of leukopenia and anti-SSB (anti-La) autoantibodies, higher prevalence of hypertension, diabetes mellitus, metabolic syndrome and lower use of antimalarial drugs [14]. This evidence concerns the gene SSB and diabetes mellitus.