There are a number of mutations that have been associated with a high risk of venous thromboembolism: protein C, protein S and antithrombin deficiencies, factor V Leiden, methylenetetrahydrofolate reductase (MTHFR), and β-fibrinogen genes mutations, lipoprotein (a), and prothrombin G20210A variant [24,25]. The gene discussed is MTHFR; the disease is venous thromboembolism.