INS and type 1 diabetes mellitus: We enrolled 26 patients with T1D (53.8% male, median age 40 years [interquartile range, 27-48.75 years], disease duration 22 years [13-27.5 years], body mass index [BMI] 24.7 [21.55-27.65], HbA1c 7.4% [6.9-7.7], TIR 61.5% [55.5-71.7], TAR 28.0% [21.0-41.0], TBR 3.0% [2.0-7.5]), treated with continuous subcutaneous insulin infusion (34.6%) or multiple daily injections of insulin (65.4%) according to a basal bolus regimen (Table 1).