Additionally, we also noted that cell cycle-related pathways (cell cycle checkpoint, cell cycle G1/S phase transition, cell cycle DNA replication and cell cycle G2/M phase transition) and tumor angiogenesis-related pathways (HIF-1 signaling pathway, VEGF signaling pathway, mTOR signaling pathway and MAPK signaling pathway) were markedly enriched [53, 55, 61–64]. This evidence concerns the gene HIF1A and neoplasm.