HIF1A and cancer: These genes were primarily manifested in cancer-associated pathways, such as cell cycle [44], focal adhesion [45, 46], ras protein signal transduction [47], canonical wnt signaling pathway [48, 49], cellular response to hypoxia [50], Notch signaling pathway [51, 52], VEGF signaling pathway [53], AMPK signaling pathway [54], HIF-1 signaling pathway [55, 56], NF-kappa B signaling pathway [57], mTOR signaling pathway [58, 59], MAPK signaling pathway [60] and HCC.