Tumor stages, YWHAB and risk scores in the TCGA cohort and gender, tumor stages, CASP3, IRAK1, MAPK1, MAPK3, YWHAB and risk scores in the ICGC cohort significantly correlated with the patient survival prognosis in univariate analysis were subjected to multivariate analysis, and the results showed that the risk score and the tumor stage were statistically significant (P < 0.05) (Fig. 5A, C). This evidence concerns the gene MAPK3 and neoplasm.