UBE2S and cancer: Then, we intersected the 22 ubiquitination-related genes and the differentially expressed ubiquitination-related genes, and obtained 5 ubiquitination-related genes, which were UBE2S, TRIM9, ASB2, FBXO40, and EBF2; UBE2S is an E2 ubiquitin-conjugating enzyme that has cancer-promoting effects in various tumors [39, 40].