Compared with normal samples, the expression of 10 SFs (HNRNPH2, SRSF4, HNRNPL, HNRNPC, SRSF9, HNRNPK, HNRNPUL1, HNRNPF, HNRNPUL2, HNRNPM) was significantly down-regulated in AML samples. The gene discussed is HNRNPUL2; the disease is acute myeloid leukemia.