Compared with normal samples, the expression of 10 SFs (HNRNPH2, SRSF4, HNRNPL, HNRNPC, SRSF9, HNRNPK, HNRNPUL1, HNRNPF, HNRNPUL2, HNRNPM) was significantly down-regulated in AML samples. This evidence concerns the gene HNRNPC and acute myeloid leukemia.