The CXCR2-ADRA1A function module generated from our data included several immune-related genes, such as CXCL5, CXCL13, RGS12, and CXCR1, indicating that the DNA methylation function module might involve in the immune response regulation in the tumor microenvironment of sMPLC. This evidence concerns the gene CXCL13 and neoplasm.