MYSM1 and anemia: Hematology analyses of the blood of Mysm1DN/DN and Mysm1−/− mice relative to the Mysm1+/+ controls, demonstrated severe hematopoietic dysfunction, characterized by macrocytic anemia, with reduction in blood erythrocyte counts, hematocrit, and hemoglobin concentration, as well as an increased in mean corpuscular volume (MCV, Fig. 2A).