MYSM1 and Decreased total leukocyte count: We conducted further hematology analyses on tamoxifen-treated CreERT2 transgenic mice of Mysm1+/fl, Mysm1fl/fl, and Mysm1DN/fl genotypes, and observed highly similar hematopoietic phenotypes in the Mysm1Δ/DN mice, including macrocytic anemia, leukopenia, and lymphocyte depletion (Fig. 2B).