Similar to a previous report in which high TBC1D10B expression was linked to a bad prognosis in stomach adenocarcinoma patients, we reveal a significant correlation of TBC1D10B expression with gender, BMI, histologic grade, T stage, pathological stage, AFP, tumor status, and residual tumor in LIHC patients, supporting the pro-oncogenic characteristics of TBC1D10B in liver cancer development. This evidence concerns the gene AFP and liver cancer.