GLP1R and obesity due to melanocortin 4 receptor deficiency: However, in analyses of obesity-related cancers, fasting GLP-1 levels were associated with lower risk (HR 0.80, 95%CI 0.65–0.99; p = 0.042) of obesity-related cancers for each 1 SD increment for the first 4 years, but after that no such association was seen (HR 1.04, 95%CI 0.86–1.25; p = 0.690).