The early mitral inflow velocity-to-early diastolic strain rate (E/SrE) a marker previously shown to be superior to E/e’ in humans with aortic stenosis for the assessment of diastolic dysfunction33, was markedly increased in the CDAA diet group compared to the CON diet group, indicating diastolic dysfunction, which was reversed by anti-IL-1β treatment (Fig. 1A). Here, IL1B is linked to aortic stenosis.