Pharmacologic inhibition of Wnt ligand signaling with the porcupine inhibitor LGK-974 or of degradation of destruction complex components with the tankyrase inhibitor G007-LK in three CAC PDXs (two Wnt wild-type, one APC-mutant) did not suppress tumor growth (Supplementary Fig. 4d). The gene discussed is APC; the disease is neoplasm.