The analysis also revealed high expression of additional genes that have been linked to poor prognosis in AML in the 24 h-p-ERK1/2 high groups, like heat shock protein 90 alpha family class A (HSP90AA1)37,38 and F2R like trypsin receptor 1 (F2RL1)39 Furthermore, we performed a paired students t-test on the 4 h versus pre-treatment sample in the 24 h-p-ERK1/2 high groups on the 689 ERK- and p38-inducible genes (Supplementary Fig. 14a, b). Here, HSP90AA1 is linked to acute myeloid leukemia.