As shown in Figure 3A, constitutive (control) and IFN-ß-induced expression (+IFN-ß) of A3A mRNA were detected in a cell line-dependent manner, i.e. negligible A3A mRNA expression was observed in 16HBE14o- (a human bronchial epithelial cell line) and MRC-5 (a human foetal lung fibroblast line) cells, whereas high A3A mRNA expression was found in the human lung adenocarcinoma-derived (epithelial-like) cell lines A549 and Calu-3. This evidence concerns the gene APOBEC3A and lung adenocarcinoma.