In addition, we also investiged the expression of IFN-γ and TNF-α in LSG tissues, showing that IFN-γ and TNF-α were expressed almost exclusively in CD8+ T cells in pSS patients, and that only a few CD8+ T cells in lymphocytic foci expressed IFN-γ and TNF-α. The gene discussed is CD8A; the disease is peeling skin syndrome.