Interestingly, the nine highly penetrant pathogenic mutations (p.R35C, p. R183X, p.A270T, p.P308L, p.S348L, p. L405V, p.R414W, p.P427fs, p.R481W) identified in TMEM175 gene were present in 14 unrelated PD patients who represent the 3.5% of the entire MNI cohort. The gene discussed is TMEM175; the disease is Parkinson disease.