Hypoxia-inducible factor 1α (HIF1α), whose overexpression occurs in many cancers as an adaptive regulator of hypoxia for tumorigenesis, is stabilized by defects in metabolic enzymes such as succinate dehydrogenase (SDH) and fumarate hydratase (FH) (Talks et al. 2000; Sharp and Bernaudin 2004; Pollard et al. 2005; Yee Koh et al. 2008). This evidence concerns the gene FH and cancer.