AEP could promote tumor progression by blocking the tumor-suppressive function of P53 [26], activating the PI3K/AKT pathway [33], remodeling of the extracellular matrix (ECM) [34], increasing endothelial permeability [35], or modulating epithelial-to-mesenchymal transition (EMT) [36]. The gene discussed is PIK3CA; the disease is neoplasm.