Interestingly, out of 13 transporters tested, depletion of CD98hc, the heavy chain required for several essential amino acid transporter complexes, the trehalose transporters Tret1-1 and the glucose and trehalose transporter MFS3 reduced average tumor volume above 50% (Fig. 1D, candidates whose mean volume is below the dashed line). The gene discussed is SLC38A7; the disease is neoplasm.