Furthermore, interestingly, it has been reported that CD98hc and its light chain LAT1 are often overexpressed and associated with poor prognosis in several aggressive cancers, such as non-small-cell lung cancer [46], glioma [47] and triple-negative breast cancers, underlining the important role of CD98hc in tumor progression. This evidence concerns the gene SLC3A2 and non-small cell lung carcinoma.