Overall, a high degree of overlap in the most enriched genes from Eμ-PRMT5/TCL1-dominant lymph node cluster LN.7, Eμ-PRMT5/TCL1-dominant spleen cluster 5.6, and Eμ-PRMT5-dominant spleen clusters 3.4 and 3.6, was observed with cells from human RT lymph node tumors with abundant PRMT5 expression (RT clusters 3 and 11). The gene discussed is PRMT5; the disease is benign neoplasm.