Clusters 3.4 and 3.6 also featured upregulation of genes implicated in large cell lymphomas, and notably overlapping with several genes enriched in RT tumors compared to matched CLL precursors, including Birc5, Cdk1, Mki67, and Npm1 (Supplemental Fig. 2F). Here, MKI67 is linked to anaplastic large cell lymphoma.