Clusters 3.4 and 3.6 also featured upregulation of genes implicated in large cell lymphomas, and notably overlapping with several genes enriched in RT tumors compared to matched CLL precursors, including Birc5, Cdk1, Mki67, and Npm1 (Supplemental Fig. 2F). This evidence concerns the gene NPM1 and B-cell chronic lymphocytic leukemia.