This included leukemogenic genes including Myc, Cd69, Cd83, AP-1 components including Fos, Jun, and Junb, tubulin-encoding genes Tuba1b and Tubb5, genes encouraging lymphoid homing including Ccr7 and Cxcr5, and mediators of immune suppression including Il-10, Ctla4, and Cd274 (Pd-L1), cumulatively providing supporting evidence for a role for PRMT5 in the advanced progression of CLL. This evidence concerns the gene FOSB and B-cell chronic lymphocytic leukemia.