Gene expression profiles of 16,004 Eμ-PRMT5/TCL1 cells and 25,886 Eμ-TCL1 cells revealed graph-based clustering of B-, T-lymphocytes, monocytes, and neutrophil cell populations with distinct transcriptional activity (Fig. 5e and Supplemental Fig. 4E), with Cd19+ /Cd5+ “CLL-like” cells demonstrating definite clustering patterns in regions with the highest cell density within each model (Supplemental Fig. 4F). Here, PRMT5 is linked to B-cell chronic lymphocytic leukemia.