PRMT5 and B-cell chronic lymphocytic leukemia: Gene expression analysis showed minimal differentially expressed genes (DEGs; n = 288 in Eμ-PRMT5, n = 222 in Eμ-TCL1) between Eμ-PRMT5 and Eμ-TCL1 splenic B cells, suggesting a similar transcriptome profile within CLL-like cells in these two models (Fig. 2i).