In our studies, Birc5 and Junb were repeatedly observed among the most enriched genes in B-cell clusters predominantly in the spleen and lymph nodes of Eμ-PRMT5 and Eμ-PRMT5/TCL1 mice, possibly implicating a PRMT5-NR4A1 axis as a major mechanism supporting the CLL-to-RT evolution. This evidence concerns the gene PRMT5 and B-cell chronic lymphocytic leukemia.