Using these studies for further comparison, Klintman and colleagues48 observed enrichment of IL-10 in RT tumors compared to circulating CLL, similar to our evaluation in Eμ-PRMT5/TCL1 spleen and lymph node tissue (Fig. 5g and Supplemental Fig. 5D), indicating a prominent role for mediators of immune suppression in CLL-to-RT evolution. This evidence concerns the gene TCL1A and B-cell chronic lymphocytic leukemia.