B-cell clusters from Eμ-PRMT5/TCL1 lymph nodes displayed enrichment of oncogenic genes, including Ly6a (Sca-1)—a marker for Myc-driven cancer stem cells in human and mouse lymphoma models38, Myc, and Il-10 as well as increased expression of markers indicating activated cell populations, including Cd274 (Pd-L1), Mki67, and Ccr7 (Supplemental Fig. 5D). Here, LY6S is linked to cancer.