Similar to that observed in spleen cells from both Eμ-PRMT5/TCL1 and Eμ-TCL1 models, Cd19+ /Cd5+ “CLL-like” cells were identified clustering in regions with high population density within the B-cell compartment in each model (Supplemental Fig. 5C). This evidence concerns the gene PRMT5 and B-cell chronic lymphocytic leukemia.