Evaluating gene expression enriched in RT LN clusters 3 and 11 amongst the most abundant clusters in the LN B-cell compartment, we observed enrichment of genes including BIRC5 (survivin), CDK1, and TCL1A, among others, likely contributing to CLL-to-RT progression by stimulating proliferation and anti-apoptotic signaling with enhanced activity along the BCR-signaling axis (Fig. 1g). This evidence concerns the gene TCL1A and B-cell chronic lymphocytic leukemia.