We previously reported inhibition of bromodomain-containing protein-4 (BRD4) to down-modulate PRMT5 along with other key genes (i.e., cMYC, BTK)55 in CLL and DLBCL, suggesting BRD4 activity may control PRMT5 gene transcription. This evidence concerns the gene BRD4 and B-cell chronic lymphocytic leukemia.