In addition to multiple trans interactions with this site (Supplemental Fig. 7A), we identified a distinct cys genomic region ~500 kb downstream from the PRMT5 start codon on chromosome 14 featuring a large enhancer (Supplemental Fig. 7B) we have previously reported having active histone marks (i.e., H3K27Ac) and BRD4 occupancy in activated CLL cells but not normal B cells55. Here, PRMT5 is linked to B-cell chronic lymphocytic leukemia.