Finally, PRPF8 is associated with the migration and invasion capacities of HCC cells by modulating FN1 splicing, FAK/AKT signaling and cytoskeletal remodeling, findings that pave the way for targeting this novel PRPF8-related pathway for the development of more specific tools for the management and treatment of HCC patients. Here, AKT1 is linked to hepatocellular carcinoma.