PRPF8 and hepatocellular carcinoma: In addition, PRPF8 silencing was associated with reductions in CDK2 and CDK4 expression in Hep3B xenografts (Fig. 4g), accompanied by reductions in the expression of key oncogenic splice variants found to be correlated with PRPF8 expression in human HCC samples, such as CCDC50S and KLF6SV1 (Fig. 4h).