PRPF8 and hepatocellular carcinoma: Interestingly, in the HCC samples from the retrospective cohort, the PRPF8 expression level was directly correlated with the expression of important oncogenic HCC-related splice variants, such as CCDC50S and KLF6SV1 (R > 0.303; p < 0.001 in both cases; Supplementary Fig. 1b).