Integrated analysis of RNAseq and CLIPseq data revealed that PRPF8 can physically interact and directly control the splicing pattern of 35 genes, including FN1, HNRNPC, ALB and RPS27A, thus suggesting that PRPF8 silencing may reduce HCC aggressiveness by altering the splicing of key cancer-related genes. Here, RPS27A is linked to cancer.