Since CD4+ cytotoxic T lymphocytes have been demonstrated to be clonally expanded in the peripheral blood of IgG4-RD patients and implicated in IgG4-RD pathogenesis [36, 37], exploring whether myelin-specific T cells contribute to IgG4-RD development in our future study will be interesting. This evidence concerns the gene CD4 and immunoglobulin G4-related sclerosing disease.