An integrative analysis of CD4+ and CD8+ T cells from the multiple-autoimmune disease methylation, including Graves’ disease (GD), RA, SLE, and systemic sclerosis (SSc), demonstrated that hypomethylation of IFN-related genes is a common feature of autoimmune diseases in CD4+ T cells [55]. The gene discussed is IFNA1; the disease is systemic sclerosis.