Strikingly, the H3K27ac level at the ETS2-SE was strongly correlated with the level of ETS2 expression in primary CRC but not in normal colon tissues, and the change of ETS2-SE activity between matched CRC and normal colon tissues largely resembled the pattern of ETS2 expression level variation in the same samples (Fig. 3C). Here, ETS2 is linked to colorectal carcinoma.