ETS2 and colorectal carcinoma: By integrating the epigenome (histone modification profiles) [22, 23] and 3D genome (promoter capture Hi-C) [7] data in CRC cell lines, we identified a distal SE located around 120 kb 3’ downstream from the transcription start site of ETS2, which was likely to interact with the ETS2 promoter and correlated with higher ETS2 expression in CRC cell lines with the presence of the SE (Fig. 2A, B).