Taken together, our study identified a novel disease-specific SE that regulates ETS2 transcription via long-range interaction in CRC and IBD and elucidated the mechanism by which an IBD-risk genetic variant affects ETS2 expression through modulating the recruitment of oncogenic transcription factor MECOM to the ETS2-SE (Fig. 5D). The gene discussed is ETS2; the disease is inflammatory bowel disease.