MECOM and colorectal carcinoma: Indeed, ChIP-seq experiments revealed the enrichment of MECOM binding across the ETS2-SE (Fig. 4B) and CUT&Tag (Cleavage Under Targets and Tagmentation) experiments confirmed its recruitment to the eQTL site (Fig. 4C) in two CRC cell lines with heterozygous alleles (Supplementary Fig. 4A).