ETS2 and colorectal carcinoma: To further explore the clinical relevance of the novel ETS2-SE, we obtained and reanalyzed the epigenome data of CRC patients from a large cohort study [14] with a focus on distal SEs and found that the level of H3K27ac across the ETS2-SE was significantly higher in primary CRC tissues than in matched normal colon tissues (p = 5.43E-6, n = 72) (Fig. 3A, B).