RT-qPCR analysis showed that the expression levels of F13A1 in human synovial tissues harvested from patients with RA were significantly higher than those in OA synovium, which were non-inflammatory control subjects against RA, or human mononuclear cells from healthy volunteers, which were monocytes and lymphocytes under non-pathological conditions. The gene discussed is F13A1; the disease is rheumatoid arthritis.