SGK1 and Alzheimer disease: In addition, while we have explored the pathophysiological role of one of the gene targets that is upregulated by the elevated H3K4me3 in AD–Sgk1 (serum and glucocorticoid-regulated kinase 1)17, it is unclear how H3K4me3-mediated transcriptional dysregulation might be linked to pathways that are destructive to synaptic integrity in AD.