SOX2 and Familial prostate cancer: Besides the NEPC markers, SLC12A5 was also positively correlated with genes that drive neuroendocrine plasticity in prostate cancer progression such as NKX2-1, MYCN, FOXA2, E2F1, POU3F2(BRN2), E2F2, ASCL1 and SOX2, whereas negatively correlated with AR, androgen-responsive genes (SPDEF, NKX3-1, and FKBP5) and NEPC repressor REST (Fig. 3F).