YTHDC1 and colorectal cancer: To further determine whether the interaction between endogenous SLC12A5 and YTHDC1 occurs in the cell nucleus, we conducted an immunofluorescence staining and found that endogenous SLC12A5 co-localized with YTHDC1 in the cell nucleus in SLC12A5 high-expressing prostate and colorectal cancer cells (Fig. 5C).