We found that overexpression of SLC12A5 in prostate cancer cells did not remarkably alter the protein levels of YTHDC1 (Supplementary Fig. S4C) and knockdown of YTHDC1 in 22RV-1 cells did not change the SLC12A5 protein levels (Supplementary Fig. S4D) either, ruling out the possible mutual regulatory effect between SLC12A5 and YTHDC1 at the protein level. Here, SLC12A5 is linked to Familial prostate cancer.