HOXB13 and Familial prostate cancer: We found that HOXB13 mRNA was up-regulated in SLC12A5-overexpressing 22RV-1 cells (Supplementary Fig. S5B) and this upregulation was partially abrogated by knocking down YTHDC1 in the SLC12A5-overexpressing 22RV-1 cells (Fig. 6D, E), suggesting that HOXB13 was the target gene of SLC12A5/YTHDC1 complex in prostate cancer.