YTHDC1 and Familial prostate cancer: We found that overexpression of SLC12A5 in prostate cancer cells did not remarkably alter the protein levels of YTHDC1 (Supplementary Fig. S4C) and knockdown of YTHDC1 in 22RV-1 cells did not change the SLC12A5 protein levels (Supplementary Fig. S4D) either, ruling out the possible mutual regulatory effect between SLC12A5 and YTHDC1 at the protein level.