SLC12A5 and colorectal cancer: In the other hand, knocking down SLC12A5 in DU145 and PC3 cells by small interfering RNAs (siRNAs) significantly decreased cell proliferation (Fig. 2E, F; Supplementary Fig. S2C–E) and cell migration (Fig. 2G, Supplementary Fig. S2F), corroborating with the findings in colorectal cancer (Ref.