Currently, however, it is not known whether all CRC cell lines that allow for inactivation of TCF7L2 or β-CATENIN share as common property high Hh/GLI or YAP activity, or whether other, yet to be identified and possibly context-dependent conditions, can render β-CATENIN and TCF7L2 dispensable. This evidence concerns the gene TCF7L2 and colorectal carcinoma.