In sum, it appears that the mitogenic effects of WNT/β-CATENIN pathway activity found in healthy IECs might be partly retained in HT29, HCT116, and SW480 CRC cells, but the strict dependence on β-CATENIN and TCF7L2 for proliferation and survival appears to be alleviated in the cancer cells. This evidence concerns the gene TCF7L2 and cancer.