Thus, it is possible that other properties of CRC cells that were reported to be influenced by WNT/β-CATENIN pathway activity, such as stemness, cell fate decisions, epithelial-mesenchymal plasticity, cell adhesion, migration, invasiveness and metastasis1,3,4,43, still depend on TCF/LEF family members and β-CATENIN. Here, HNF4A is linked to colorectal carcinoma.