As an additional corollary of the observed context-dependence and divergence of β-CATENIN and TCF7L2 activities, it is virtually impossible to extrapolate from work with a small number of cell lines to colorectal cancer in general, and the significance of results from high throughput inhibitor screens which often are based on a single cell line, is likely to be extremely limited. The gene discussed is TCF7L2; the disease is colorectal cancer.